856307-27-2
856307-27-2 structure
- Name: 4-Methylamino antipyrine hydrochloride
- Chemical Name: 3H-Pyrazol-3-one, 1,2-dihydro-1,5-dimethyl-4-(methylamino)-2-phenyl-, hydrochloride
- CAS Number: 856307-27-2
- Molecular Formula: C12H16ClN3O
- Molecular Weight: 253.72800
- Catalog: Signaling Pathways Immunology/Inflammation COX
- Create Date: 2016-12-29 03:31:13
- Modify Date: 2023-03-02 10:59:09
-
4-Methylamino antipyrine hydrochloride is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. Metamizole is an nonopioid analgesic drug and can be used for pain and fever[1][2][3]. 4-Methylamino antipyrine hydrochloride has analgesic, antipyretic, and relatively weak antiinflammatory properties[2].
| Name | 3H-Pyrazol-3-one, 1,2-dihydro-1,5-dimethyl-4-(methylamino)-2-phenyl-, hydrochloride |
|---|---|
| Synonyms |
Metamizole Impurity C (4-Methylaminoantipyrine) HCl
Antipyrine, 4-(methylamino)-, hydrochloride Metamizole Impurity C |
| Description | 4-Methylamino antipyrine hydrochloride is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. Metamizole is an nonopioid analgesic drug and can be used for pain and fever[1][2][3]. 4-Methylamino antipyrine hydrochloride has analgesic, antipyretic, and relatively weak antiinflammatory properties[2]. |
|---|---|
| Related Catalog | |
| Target |
COX[2][3] |
| In Vitro | Metamizole is a prodrug which, at room temperature and in an atmosphere with oxygen, is spontaneously, nonenzymatically converted to 4-Methylamino antipyrine. Subsequently, the N-methyl side chain of 4-Methylamino antipyrine is oxidized to yield 4-formylaminoantipyrine, which is further converted to 4-aminoantipyrine. Metamizole in aqueous solution and in the presence of oxygen consists of a group of several pyrazolone derivatives of which 4-Methylamino antipyrine is pharmacologically the most important[2]. |
| In Vivo | The aim of this study is to assess the pharmacokinetics of its active metabolites 4-Methylamino antipyrine in male piglets after a single intramuscular injection of Metamizole. Eight healthy male piglets are administered Metamizole (100 mg/kg) intramuscularly. 4-Methylamino antipyrine plasma concentrations are quantitatively detectable from 0.25 to 48 h. The average maximum concentration of 4-Methylamino antipyrine is of 47.59 mg/mL. The average half-lives is 8.57 h for 4-Methylamino antipyrine[1]. |
| References |
| Molecular Formula | C12H16ClN3O |
|---|---|
| Molecular Weight | 253.72800 |
| Exact Mass | 253.09800 |
| PSA | 38.96000 |
| LogP | 2.40110 |