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17355-10-1

17355-10-1 structure
17355-10-1 structure
  • Name: Tyrosylleucine
  • Chemical Name: Tyr-Leu
  • CAS Number: 17355-10-1
  • Molecular Formula: C15H22N2O4
  • Molecular Weight: 294.35
  • Catalog: Research Areas Neurological Disease
  • Create Date: 2019-01-21 12:41:57
  • Modify Date: 2025-08-20 18:10:04
  • Tyrosylleucine (Tyr-Leu, YL), an orally active dipeptide, exhibits a potent antidepressant-like activity[1].
Name Tyr-Leu
Synonyms N-L-Tyrosyl-L-leucin
TYR-LEU
L-Leucine,N-L-tyrosyl
N-L-tyrosyl-L-leucine
tyrosylleucine
L-Tyrosyl-L-leucine
L-Tyrosyl-L-leucin
H-TYR-LEU-OH
L-tyrosine-L-leucine
TYR-LEU CRYSTALLINE
Description Tyrosylleucine (Tyr-Leu, YL), an orally active dipeptide, exhibits a potent antidepressant-like activity[1].
Related Catalog
In Vivo Tyrosylleucine (YL), administered orally, intracerebroventricularly, or intraperitoneally exhibits a potent antidepressant-like activity in the forced swim and tail suspension tests in naïve mice[1]. Animal Model: Male ddY mice (24-27 g)[1] Dosage: 0.1-30 mg/kg, i.p.; 0.1-1.0 nmol/mouse, i.c.v.; 30-100 mg/kg, p.o. Administration: Administered orally, intracerebroventricularly, or intraperitoneally Result: Decreased immobility time after intraperitoneal (1-30 mg/kg) and intracerebroventricular (0.3-1 nmol/mouse) administrations in the FST. Exhibited a potent antidepressant-like activity in the forced swim and tail suspension tests in naïve mice.
References

[1]. Takafumi Mizushige, et al. Dipeptide tyrosyl-leucine exhibits antidepressant-like activity in mice. Sci Rep. 2020 Feb 10;10(1):2257.

[2]. Norimasa Kanegawa, et al. Dipeptide Tyr-Leu (YL) exhibits anxiolytic-like activity after oral administration via activating serotonin 5-HT1A, dopamine D1 and GABAA receptors in mice. FEBS Lett. 2010 Feb 5;584(3):599-604.
Density 1.218g/cm3
Boiling Point 575.9ºC at 760 mmHg
Molecular Formula C15H22N2O4
Molecular Weight 294.35
Flash Point 302.1ºC
Exact Mass 294.15800
PSA 112.65000
LogP 1.96870
Vapour Pressure 4.2E-14mmHg at 25°C
Index of Refraction 1.565
WGK Germany 3
HS Code 2924299090
Precursor  1

DownStream  0

HS Code 2924299090
Summary 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
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