73731-87-0

73731-87-0 structure

Name: 2-[3-(4-Hydroxyphenyl)propyl]-5-methoxyphenol
Chemical Name: Broussonin A
CAS Number: 73731-87-0
Molecular Formula: C₁₆H₁₈O₃
Molecular Weight: 258.312
Catalog: Natural product Phenols
Create Date: 2017-07-01 06:44:19
Modify Date: 2024-01-15 10:10:31
Broussonin A is a potent BChE inhibitor, with an IC50 of 4.16 µM. Broussonin A is a diarylpropane natural product that can be isolated from the bark of Broussonetia papyrifera after solid fermentation[1][2][3].

Name	Broussonin A
Synonyms	2-[3-(4-Hydroxyphenyl)propyl]-5-methoxyphenol Phenol, 2-[3-(4-hydroxyphenyl)propyl]-5-methoxy-

Description	Broussonin A is a potent BChE inhibitor, with an IC50 of 4.16 µM. Broussonin A is a diarylpropane natural product that can be isolated from the bark of Broussonetia papyrifera after solid fermentation[1][2][3].
Related Catalog	Research Areas >> Cancer Research Areas >> Cardiovascular Disease Signaling Pathways >> Neuronal Signaling >> AChE
Target	BChE:4.16 μM (IC50)
In Vitro	Broussonin A（0.1-10 µM，30 分钟）通过调节细胞周期相关蛋白的表达和视网膜母细胞瘤蛋白的磷酸化状态来抑制 VEGF-A 刺激的内皮细胞增殖[1]。 Broussonin A（0-10 µM，30 分钟）消除 VEGF-A 刺激的血管生成反应，包括大鼠主动脉环的内皮细胞迁移、侵袭、管形成和微血管形成[1]。
References	[1]. Kim JH, et al. Broussonin A- and B-mediated inhibition of angiogenesis by blockade of VEGFR-2 signalling pathways and integrin β1 expression. J Cell Mol Med. 2022 Feb;26(4):1194-1205. [2]. Lee JP, et al. Potent inhibition of acetylcholinesterase by sargachromanol I from Sargassum siliquastrum and by selected natural compounds. Bioorg Chem. 2019 Aug;89:103043. [3]. Chang C F, et al. Bioactive compounds from the bark of Broussonetia papyrifera after solid fermentation with a white rot fungus Perenniporia tephropora[J]. Journal of Wood Chemistry and Technology, 2020:1-14.