98603-84-0

98603-84-0 structure

Name: Sialyl-Lewis X
Chemical Name: sialyl lewis x
CAS Number: 98603-84-0
Molecular Formula: C₃₁H₅₂N₂O₂₃
Molecular Weight: 820.74400
Catalog: Biochemical Carbohydrate Oligosaccharide
Create Date: 2018-08-20 18:23:50
Modify Date: 2024-01-03 21:32:47
Sialyl-Lewis X (sLeX) is a sialylated fucosylated tetrasaccharide, an endogenous antigen. Sialyl-Lewis X is a high-affinity ligand for selectins (E-, P-, and L-selectin)[1]. Sialyl-Lewis X binds to ELAM-1 and CD62 and has the ability to inhibits CD62-mediated neutrophil recruitment to sites of inflammation[2].

Name	sialyl lewis x
Synonyms	SLEX,SODIUM SALT S LEX Sialyl Lex tri SSEA 1 3'-SIALYL-LEWIS-X TETRASACCHARIDE MFCD00270073 Lewis Sugars 3'-SIALYL-LEWISX 3'-SIALYL LEWIS

Description	Sialyl-Lewis X (sLeX) is a sialylated fucosylated tetrasaccharide, an endogenous antigen. Sialyl-Lewis X is a high-affinity ligand for selectins (E-, P-, and L-selectin)[1]. Sialyl-Lewis X binds to ELAM-1 and CD62 and has the ability to inhibits CD62-mediated neutrophil recruitment to sites of inflammation[2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
In Vitro	Sialyl-Lewis X is a high-affinity ligand of CD62, Antibodies [mAb CSLEX (IgM; anti-sLeX)] to sLeX inhibit CD62-mediated binding of HL-60 cells to activated platelets[1]. Liposomes containing glycolipids with the sLeX structure prevents adhesion of HL-60 cells and human neutrophils. HL-60 cell adhesion is partially inhibited (50%) by liposomes containing Lex at 5 μg/ml. However, sLeX liposomes give maximal inhibition at only 1 ug/ml. sLeX liposomes inhibits adhesion with a 10-fold higher affinity than Lex liposomes[1]. CD62 binding of neutrophils to activated platelets is inhibited a soluble human milk oligosaccharide that contains the LeX structure. the sLeX sugar is a 30-fold more potent inhibitor than the nonsialylated Lex sugar, which requires 2 μg/ml and 54 μg/ml to achieve 50% inhibition of neutrophil adhesion, respectively[1].
References	[1]. M J Polley, et al. CD62 and Endothelial Cell-Leukocyte Adhesion Molecule 1 (ELAM-1) Recognize the Same Carbohydrate Ligand, sialyl-Lewis X. Proc Natl Acad Sci U S A. 1991 Jul 15;88(14):6224-8. [2]. L A Lasky, et al. Selectins: Interpreters of Cell-Specific Carbohydrate Information During Inflammation. Science

Density	1.66g/cm3
Boiling Point	1285.8ºC at 760mmHg
Molecular Formula	C₃₁H₅₂N₂O₂₃
Molecular Weight	820.74400
Flash Point	731.4ºC
Exact Mass	820.29600
PSA	410.71000
Index of Refraction	1.653
Storage condition	−20°C
Stability	Store in freezer

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3

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