354811-10-2

354811-10-2 structure

Name: (5-PHENYL-2-UREIDO)THIOPHENE-3-CARBOXAMIDE
Chemical Name: 2-(carbamoylamino)-5-phenylthiophene-3-carboxamide
CAS Number: 354811-10-2
Molecular Formula: C₁₂H₁₁N₃O₂S
Molecular Weight: 261.30
Catalog: Signaling Pathways NF-κB IKK
Create Date: 2018-12-04 07:22:59
Modify Date: 2024-01-13 11:20:27
IKK2-IN-4 (compound 4) is a potent IKK-2 inhibitor, with an IC50 of 25 nM. IKK2-IN-4 can inhibit the LPS-induced production of TNFα in PBMCs[1].

Name	2-(carbamoylamino)-5-phenylthiophene-3-carboxamide
Synonyms	IN1462 HMS3229F13 HMS2043P17 IKK-2 Inhibitor VI

Description	IKK2-IN-4 (compound 4) is a potent IKK-2 inhibitor, with an IC50 of 25 nM. IKK2-IN-4 can inhibit the LPS-induced production of TNFα in PBMCs[1].
Related Catalog	Signaling Pathways >> NF-κB >> IKK Research Areas >> Inflammation/Immunology
Target	IKK-2:25 nM (IC50)
References	[1]. Baxter A, et, al. Hit-to-lead studies: the discovery of potent, orally active, thiophenecarboxamide IKK-2 inhibitors. Bioorg Med Chem Lett. 2004 Jun 7;14(11):2817-22.