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1860797-76-7

1860797-76-7 structure

1860797-76-7 structure

Name: VU6004909
Chemical Name: VU6004909
CAS Number: 1860797-76-7
Molecular Formula: C₂₁H₁₅FN₂O₄
Molecular Weight: 378.35
Catalog: Signaling Pathways GPCR/G Protein mGluR
Create Date: 2023-12-19 02:02:49
Modify Date: 2024-01-03 12:50:39
VU6004909 is a mGlu5 receptor positive allosteric modulator (pEC50: 7.59). VU6004909 shows antipsychotic-like effects. VU6004909 can reverse MK801-induced cortical hyperactivity and cognitive deficits[1][2].

Name	VU6004909

Description	VU6004909 is a mGlu5 receptor positive allosteric modulator (pEC50: 7.59). VU6004909 shows antipsychotic-like effects. VU6004909 can reverse MK801-induced cortical hyperactivity and cognitive deficits[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> mGluR Research Areas >> Neurological Disease
References	[1]. Dogra S, et al. Metabotropic Glutamate Receptors As Emerging Targets for the Treatment of Schizophrenia. Mol Pharmacol. 2022 May;101(5):275-285. [2]. Garcia-Barrantes PM, et al. Lead optimization of the VU0486321 series of mGlu(1) PAMs. Part 2: SAR of alternative 3-methyl heterocycles and progress towards an in vivo tool. Bioorg Med Chem Lett. 2016 Feb 1;26(3):751-756.

Molecular Formula	C₂₁H₁₅FN₂O₄
Molecular Weight	378.35

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