2675452-91-0

2675452-91-0 structure

Name: PFI-6
Chemical Name: PFI-6
CAS Number: 2675452-91-0
Molecular Formula: C₂₂H₂₁N₃O₄
Molecular Weight: 391.42
Catalog: Research Areas Others
Create Date: 2024-04-02 23:04:44
Modify Date: 2026-04-07 12:37:32
PFI-6 is a non-cytotoxic and selective MLLT1/3 probe targeting the YEATS domain of MLLT1 (ENL/YEATS1) and MLLT3 (AF9/YEATS3). PFI-6 shows IC50 values of 140 nM and 160 nM for MLLT1 and MLLT3, respectively. PFI-6 can serve as a molecular tool to explore the role of MLLT1/3 in various diseases and related genome validation studies[1].

Name	PFI-6

Description	PFI-6 is a non-cytotoxic and selective MLLT1/3 probe targeting the YEATS domain of MLLT1 (ENL/YEATS1) and MLLT3 (AF9/YEATS3). PFI-6 shows IC50 values of 140 nM and 160 nM for MLLT1 and MLLT3, respectively. PFI-6 can serve as a molecular tool to explore the role of MLLT1/3 in various diseases and related genome validation studies[1].
Related Catalog	Research Areas >> Others
Target	IC50: 140 nM (MLLT1); 160 nM (MLLT3)[1].
References	[1]. Raux B, et al. Discovery of PFI-6, a small-molecule chemical probe for the YEATS domain of MLLT1 and MLLT3. Bioorg Med Chem Lett. 2023 Nov 7:129546.

Molecular Formula	C₂₂H₂₁N₃O₄
Molecular Weight	391.42