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2761424-76-2

2761424-76-2 structure

2761424-76-2 structure

Name: mGluR5 antagonist-1
Chemical Name: mGluR5 antagonist-1
CAS Number: 2761424-76-2
Molecular Formula: C₂₃H₁₈N₄O₂
Molecular Weight: 382.41
Catalog: Signaling Pathways GPCR/G Protein mGluR
Create Date: 2023-12-18 16:57:42
Modify Date: 2025-09-04 16:49:58
mGluR5 antagonist-1 (compound 10) is a high-affinity mGluR5 antagonist, with an IC50 value of 11.5 nM. mGluR5 antagonist-1 has anti-depressant effect[1].

Name	mGluR5 antagonist-1

Description	mGluR5 antagonist-1 (compound 10) is a high-affinity mGluR5 antagonist, with an IC50 value of 11.5 nM. mGluR5 antagonist-1 has anti-depressant effect[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> GPCR/G Protein >> mGluR
References	[1]. Yonglei Du, et al. Novel substituted 4-(Arylethynyl)-Pyrrolo[2,3-d]pyrimidines negative allosteric modulators (NAMs) of the metabotropic glutamate receptor subtype 5 (mGlu5) Treat depressive disorder in mice. Eur J Med Chem. 2023.

Molecular Formula	C₂₃H₁₈N₄O₂
Molecular Weight	382.41

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