908856-14-4

908856-14-4 structure

Name: ICMT-IN-54
Chemical Name: ICMT-IN-54
CAS Number: 908856-14-4
Molecular Formula: C₂₉H₄₅NO₃S
Molecular Weight: 487.74
Catalog: Research Areas Cancer
Create Date: 2024-02-06 11:18:06
Modify Date: 2024-02-06 11:18:06
ICMT-IN-54 (compound 7c) is an adamantyl analogue and an ICMT inhibitor (IC50=12.4 μM), which can inhibit ICMT Methylation. ICMT-in-54 inhibits BFC (N-biotinyl-(6-aminohexanoic)-S-farnesyl-L-cysteine) methylation in saccharomyces cerevisiae expressing ICMT, which is an indirect effect of inhibiting ICMT methylation[1].

Name	ICMT-IN-54

Description	ICMT-IN-54 (compound 7c) is an adamantyl analogue and an ICMT inhibitor (IC50=12.4 μM), which can inhibit ICMT Methylation. ICMT-in-54 inhibits BFC (N-biotinyl-(6-aminohexanoic)-S-farnesyl-L-cysteine) methylation in saccharomyces cerevisiae expressing ICMT, which is an indirect effect of inhibiting ICMT methylation[1].
Related Catalog	Research Areas >> Cancer
Target	IC50: 12.4 μM (human ICMT)[1]
References	[1]. Donelson JL, et al. Amide-substituted farnesylcysteine analogs as inhibitors of human isoprenylcysteine carboxyl methyltransferase. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4420-3.

Molecular Formula	C₂₉H₄₅NO₃S
Molecular Weight	487.74