1418293-39-6

1418293-39-6 structure

Name: HDAC4-IN-1
Chemical Name: HDAC4-IN-1
CAS Number: 1418293-39-6
Molecular Formula: C₁₆H₁₉F₃N₄O₂
Molecular Weight: 356.34
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2024-03-21 18:09:05
Modify Date: 2024-03-21 18:09:05
HDAC4-IN-1 (compound 1a) is a class IIa HDACI inhibitor (IC50=0.077 μM). HDAC4-IN-1 can enhance Caspase-induced Apoptosis. HDAC4-IN-1 has anticancer activity. HDAC4-IN-1 can be used in the research of drug combination against cancer[1].

Name	HDAC4-IN-1

Description	HDAC4-IN-1 (compound 1a) is a class IIa HDACI inhibitor (IC50=0.077 μM). HDAC4-IN-1 can enhance Caspase-induced Apoptosis. HDAC4-IN-1 has anticancer activity. HDAC4-IN-1 can be used in the research of drug combination against cancer[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC
Target	HDAC2:6.13 μM (IC50) HDAC4:0.012 μM (IC50) HDAC6:5.79 μM (IC50) HDAC8:4.26 μM (IC50)
References	[1]. Asfaha Y, et al. 5-(Trifluoromethyl)-1,2,4-oxadiazole (TFMO)-based highly selective class IIa HDAC inhibitors exhibit synergistic anticancer activity in combination with bortezomib. Eur J Med Chem. 2023 Nov 10;263:115907.

Molecular Formula	C₁₆H₁₉F₃N₄O₂
Molecular Weight	356.34