2592436-21-8

2592436-21-8 structure

Name: GRK2 Inhibitor 2
Chemical Name: GRK2 Inhibitor 2
CAS Number: 2592436-21-8
Molecular Formula: C₁₉H₁₆N₄O₂
Molecular Weight: 332.36
Catalog: Research Areas Cardiovascular Disease
Create Date: 2024-01-16 20:17:18
Modify Date: 2024-01-16 20:17:18
GRK2 Inhibitor 2 (Compound 8h) is a GRK2 inhibitor (IC50: 19 nM). GRK2 Inhibitor 2 also inhibits Aurora-A (IC50: 137 nM). GRK2 Inhibitor 2 promotes β-AR-mediated cAMP accumulation in GRK2-overexpressed HEK293 cells. GRK2 Inhibitor 2 can be used for research of congestive heart failure (HF)[1].

Name	GRK2 Inhibitor 2

Description	GRK2 Inhibitor 2 (Compound 8h) is a GRK2 inhibitor (IC50: 19 nM). GRK2 Inhibitor 2 also inhibits Aurora-A (IC50: 137 nM). GRK2 Inhibitor 2 promotes β-AR-mediated cAMP accumulation in GRK2-overexpressed HEK293 cells. GRK2 Inhibitor 2 can be used for research of congestive heart failure (HF)[1].
Related Catalog	Research Areas >> Cardiovascular Disease
References	[1]. Xu G, et al. Hit-to-lead optimization and discovery of a potent, and orally bioavailable G protein coupled receptor kinase 2 (GRK2) inhibitor. Bioorg Med Chem Lett. 2020 Dec 1;30(23):127602.

Molecular Formula	C₁₉H₁₆N₄O₂
Molecular Weight	332.36