313552-29-3

313552-29-3 structure

Name: BMS-684
Chemical Name: BMS-684
CAS Number: 313552-29-3
Molecular Formula: C₂₇H₂₆N₄O₃
Molecular Weight: 454.52
Catalog: Research Areas Cancer
Create Date: 2024-03-07 22:56:57
Modify Date: 2024-03-07 22:56:57
BMS-684 is a selective DGKα inhibitor with an IC50 of 15 nM. BMS-684 inhibits DGKα kinase activity with >100-fold selectivity over the related DGK type I family members DGKβ and DGKγ. BMS-684 does not inhibit any of the other seven DGK isozymes[1].

Name	BMS-684

Description	BMS-684 is a selective DGKα inhibitor with an IC50 of 15 nM. BMS-684 inhibits DGKα kinase activity with >100-fold selectivity over the related DGK type I family members DGKβ and DGKγ. BMS-684 does not inhibit any of the other seven DGK isozymes[1].
Related Catalog	Research Areas >> Cancer
Target	IC50: 15 nM (DGKα)[1]
References	[1]. Michael Wichroski, et al. DGKα/ζ inhibitors combine with PD-1 checkpoint therapy to promote T cell-mediated antitumor immunity. Sci Transl Med. 2023 Oct 25;15(719):eadh1892.

Molecular Formula	C₂₇H₂₆N₄O₃
Molecular Weight	454.52