1300735-76-5

1300735-76-5 structure

Name: BET-IN-20
Chemical Name: BET-IN-20
CAS Number: 1300735-76-5
Molecular Formula: C₂₅H₂₄N₄O₂
Molecular Weight: 412.48
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2024-02-05 09:08:52
Modify Date: 2024-02-05 09:08:52
BET-IN-20 (compound 10) is an inhibitor of BRD4 BD1 (IC50=1.9 nM) with anticancer activity. BET-IN-20 can promote acute myeloid leukemia (AML) cell apoptosis and arrest the cell cycle in the G0/G1 phase. BET-IN-20 also inhibits c-Myc and CDK6 and enhances PARP cleavage[1].

Name	BET-IN-20

Description	BET-IN-20 (compound 10) is an inhibitor of BRD4 BD1 (IC50=1.9 nM) with anticancer activity. BET-IN-20 can promote acute myeloid leukemia (AML) cell apoptosis and arrest the cell cycle in the G0/G1 phase. BET-IN-20 also inhibits c-Myc and CDK6 and enhances PARP cleavage[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain
Target	IC50: 1.9 nM (BRD4 BD1)[1]
References	[1]. Yu S et al. Discovery of (R)-4-(8-methoxy-2-methyl-1-(1-phenylethy)-1H-imidazo [4, 5-c] quinnolin-7-yl)-3, 5-dimethylisoxazole as a potent and selective BET inhibitor for treatment of acute myeloid leukemia (AML) guided by FEP calculation[J]. European Journal of Medicinal Chemistry, 2023: 115924.

Molecular Formula	C₂₅H₂₄N₄O₂
Molecular Weight	412.48