1243063-73-1

1243063-73-1 structure

Name: Beclin1-ATG14L interaction inhibitor 1
Chemical Name: Beclin1-ATG14L interaction inhibitor 1
CAS Number: 1243063-73-1
Molecular Formula: C₂₃H₂₄N₄O₅S
Molecular Weight: 468.53
Catalog: Signaling Pathways Autophagy Autophagy
Create Date: 2024-02-03 20:55:44
Modify Date: 2024-02-03 20:55:44
Beclin1-ATG14L interaction inhibitor 1 (com 19) is a selective Beclin1-ATG14L interaction inhibitor. This protein interaction mechanism specifically targets complex I of the lipid kinase VPS34 without affecting complex II. Because the integrity of VPS34 complex II depends on the Beclin 1-UVRAG interaction. Beclin1-ATG14L interaction inhibitor 1 can disrupt the formation of VPS34 complex I and inhibit autophagy, but does not affect complex II-related vesicle transport[1].

Name	Beclin1-ATG14L interaction inhibitor 1

Description	Beclin1-ATG14L interaction inhibitor 1 (com 19) is a selective Beclin1-ATG14L interaction inhibitor. This protein interaction mechanism specifically targets complex I of the lipid kinase VPS34 without affecting complex II. Because the integrity of VPS34 complex II depends on the Beclin 1-UVRAG interaction. Beclin1-ATG14L interaction inhibitor 1 can disrupt the formation of VPS34 complex I and inhibit autophagy, but does not affect complex II-related vesicle transport[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Autophagy >> Autophagy
References	[1]. Pavlinov I, et al. Beclin 1-ATG14L Protein-Protein Interaction Inhibitor Selectively Inhibits Autophagy through Disruption of VPS34 Complex I. J Am Chem Soc. 2020 May 6;142(18):8174-8182.

Molecular Formula	C₂₃H₂₄N₄O₅S
Molecular Weight	468.53