1835734-92-3

1835734-92-3 structure

Name: AY77
Chemical Name: AY77
CAS Number: 1835734-92-3
Molecular Formula: C₂₁H₃₂N₄O₄
Molecular Weight: 404.50
Catalog: Signaling Pathways GPCR/G Protein Protease-Activated Receptor (PAR)
Create Date: 2024-01-20 17:57:28
Modify Date: 2024-01-20 17:57:28
AY77 is a calcium-biased PAR2 agonist. AY77 shows an EC50 of 0.17 and 2 nM in PAR2-mediated the activation in the Gq pathway and recruitment of β-arrestin-2, respectively. AY77 potently induces intracellular Ca2+ release[1][2].

Name	AY77

Description	AY77 is a calcium-biased PAR2 agonist. AY77 shows an EC50 of 0.17 and 2 nM in PAR2-mediated the activation in the Gq pathway and recruitment of β-arrestin-2, respectively. AY77 potently induces intracellular Ca2+ release[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> Protease-Activated Receptor (PAR) Research Areas >> Inflammation/Immunology
Target	PAR2[1]
References	[1]. Klösel I, et al. Discovery of Novel Nonpeptidic PAR2 Ligands. ACS Med Chem Lett. 2020 May 22;11(6):1316-1323. [2]. Jiang Y, et al. Biased Signaling by Agonists of Protease Activated Receptor 2. ACS Chem Biol. 2017 May 19;12(5):1217-1226.

Molecular Formula	C₂₁H₃₂N₄O₄
Molecular Weight	404.50