2730432-72-9

2730432-72-9 structure

Name: ALK/EGFR-IN-3
Chemical Name: ALK/EGFR-IN-3
CAS Number: 2730432-72-9
Molecular Formula: C₂₇H₃₄ClN₇O₃S
Molecular Weight: 572.12
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK ALK
Create Date: 2024-01-16 21:29:40
Modify Date: 2024-01-16 21:29:40
ALK/EGFR-IN-3 is a dual inhibitor of ALK and EGFR. ALK/EGFR-IN-3 inhibits the cell proliferation of H1975, PC9, and Baf3-EML4-ALK cancer cell lines with IC50s of 0.1360, 0.0332, and 0.0339 μM, respectively[1].

Name	ALK/EGFR-IN-3

Description	ALK/EGFR-IN-3 is a dual inhibitor of ALK and EGFR. ALK/EGFR-IN-3 inhibits the cell proliferation of H1975, PC9, and Baf3-EML4-ALK cancer cell lines with IC50s of 0.1360, 0.0332, and 0.0339 μM, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ALK
References	[1]. An B, et al. Discovery of potent and effective inhibitors containing sulfoxide structures targeting EML4-ALK rearrangement and EGFR mutant non-small cell lung cancer. Bioorg Chem. 2023 Sep;138:106653.

Molecular Formula	C₂₇H₃₄ClN₇O₃S
Molecular Weight	572.12