2918262-09-4

2918262-09-4 structure

Name: AD4
Chemical Name: AD4
CAS Number: 2918262-09-4
Molecular Formula: C₅₅H₇₈N₄O₁₅
Molecular Weight: 1035.23
Catalog: Signaling Pathways PROTAC PROTAC
Create Date: 2024-03-07 20:16:17
Modify Date: 2024-03-07 20:16:17
AD4 is an artemisinin derivative that is a proteolytic targeting chimera (PROTAC) targeting PCLAF. AD4 can effectively degrade PCLAF in RS4;11 cells (IC50: 0.6 nM), thereby activating the p21/Rb axis and exerting anti-tumor activity. AD4 also prolonged survival of RS4;11-transplanted NOD/SCID mice, with in vivo efficacy[1].

Name	AD4

Description	AD4 is an artemisinin derivative that is a proteolytic targeting chimera (PROTAC) targeting PCLAF. AD4 can effectively degrade PCLAF in RS4;11 cells (IC50: 0.6 nM), thereby activating the p21/Rb axis and exerting anti-tumor activity. AD4 also prolonged survival of RS4;11-transplanted NOD/SCID mice, with in vivo efficacy[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others Signaling Pathways >> PROTAC >> PROTAC
Target	IC50: 0.6 nM (PCLAF/KIAA0101)[1]
References	[1]. Li Y, et al. Facilitated Drug Repurposing with Artemisinin-Derived PROTACs: Unveiling PCLAF as a Therapeutic Target. J Med Chem. 2023 Aug 24;66(16):11335-11350..

Molecular Formula	C₅₅H₇₈N₄O₁₅
Molecular Weight	1035.23