1822810-13-8

1822810-13-8 structure

Name: Monomethyl auristatin E intermediate-5
Chemical Name: tert-Butyl 4-(((benzyloxy)carbonyl)amino)-5-methyl-3-oxohexanoate
CAS Number: 1822810-13-8
Molecular Formula: C₁₉H₂₇NO₅
Molecular Weight: 349.42
Catalog: Research Areas Cancer
Create Date: 2024-03-15 09:28:13
Modify Date: 2024-03-15 09:28:13
Monomethyl auristatin E intermediate-5 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs)[1].

Name	tert-Butyl 4-(((benzyloxy)carbonyl)amino)-5-methyl-3-oxohexanoate

Description	Monomethyl auristatin E intermediate-5 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75(7):1376-87.