301313-42-8

301313-42-8 structure

Name: Sirt1/2-IN-3
Chemical Name: Sirt1/2-IN-3
CAS Number: 301313-42-8
Molecular Formula: C₁₇H₁₄ClNO₄S
Molecular Weight: 363.82
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2023-10-25 17:53:29
Modify Date: 2025-08-25 23:27:27
Sirt1/2-IN-3 (compound PS9) is a dual inhibitor of SIRT1/2 with IC50s of 1.4 μM (SIRT1) and 2.0 μM (SIRT2), respsectivley. Sirt1/2-IN-3 completely blocks p53 deacetylation, and increase of p53 and α-tubulin acetylation. Sirt1/2-IN-3 induces apoptosis and shows anti-proliferation activity against human leukemia cell lines[1].

Name	Sirt1/2-IN-3

Description	Sirt1/2-IN-3 (compound PS9) is a dual inhibitor of SIRT1/2 with IC50s of 1.4 μM (SIRT1) and 2.0 μM (SIRT2), respsectivley. Sirt1/2-IN-3 completely blocks p53 deacetylation, and increase of p53 and α-tubulin acetylation. Sirt1/2-IN-3 induces apoptosis and shows anti-proliferation activity against human leukemia cell lines[1].
Related Catalog	Signaling Pathways >> Epigenetics >> Sirtuin Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin
Target	IC50: 1.4 μM (SIRT1), 2.0 μM (SIRT2), 72.3 μM (SIRT3)[1]
References	[1]. Cai H, et al. Discovery of Novel SIRT1/2 Inhibitors with Effective Cytotoxicity against Human Leukemia Cells. J Chem Inf Model. 2023 Aug 14;63(15):4780-4790.

Molecular Formula	C₁₇H₁₄ClNO₄S
Molecular Weight	363.82