444914-19-6

444914-19-6 structure

Name: Lepadin E
Chemical Name: Lepadin E
CAS Number: 444914-19-6
Molecular Formula: C₂₆H₄₇NO₃
Molecular Weight: 421.66
Catalog: Signaling Pathways Apoptosis Ferroptosis
Create Date: 2024-09-15 12:08:03
Modify Date: 2024-09-15 12:08:03
Lepadin E is a significantly cytotoxic ferroptosis inducer that induces iron death through the classical p53-SLC7A11-GPX4 pathway. Lepadin E promoted p53 expression, decreases SLC7A11 and GPX4 levels, and leads to increased ROS and lipid peroxide production, and upregulated ACSL4 expression, thus causes cell death. Lepadin E has significant antitumor effect[1].

Name	Lepadin E

Description	Lepadin E is a significantly cytotoxic ferroptosis inducer that induces iron death through the classical p53-SLC7A11-GPX4 pathway. Lepadin E promoted p53 expression, decreases SLC7A11 and GPX4 levels, and leads to increased ROS and lipid peroxide production, and upregulated ACSL4 expression, thus causes cell death. Lepadin E has significant antitumor effect[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Apoptosis >> MDM-2/p53 Signaling Pathways >> Apoptosis >> Ferroptosis
In Vivo	Lepadin E
References	[1]. Wang W, et al. Marine Alkaloid Lepadins E and H Induce Ferroptosis for Cancer Chemotherapy. J Med Chem. 2023 Aug 24;66(16):11201-11215.

Molecular Formula	C₂₆H₄₇NO₃
Molecular Weight	421.66