2883046-06-6

2883046-06-6 structure

Name: JMJD3/HDAC-IN-1
Chemical Name: JMJD3/HDAC-IN-1
CAS Number: 2883046-06-6
Molecular Formula: C₂₁H₃₀N₆O₂
Molecular Weight: 398.50
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2023-12-04 20:45:34
Modify Date: 2024-01-23 15:58:53
JMJD3/HDAC-IN-1 (compound A5b) is a dual inhibitor targeting Jumonji domain-containing protein demethylase 3 (JMJD3) and histone deacetylase (HADC1, IC50=16 nM). JMJD3/HDAC-IN-1 promotes hypermethylation of histone H3K27 and hyperacetylation of H3K9, and also cleaves caspase-7 and PARP to induce apoptosis. JMJD3/HDAC-IN-1 effectively inhibits cancer cell cloning, migration, and invasion[1].

Name	JMJD3/HDAC-IN-1

Description	JMJD3/HDAC-IN-1 (compound A5b) is a dual inhibitor targeting Jumonji domain-containing protein demethylase 3 (JMJD3) and histone deacetylase (HADC1, IC50=16 nM). JMJD3/HDAC-IN-1 promotes hypermethylation of histone H3K27 and hyperacetylation of H3K9, and also cleaves caspase-7 and PARP to induce apoptosis. JMJD3/HDAC-IN-1 effectively inhibits cancer cell cloning, migration, and invasion[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Histone Demethylase Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC
Target	IC50: 16 nM (HDAC1), 534 nM (HDAC6)[1]
References	[1]. Li A, et al. Design, synthesis and biological evaluation of pyrimidine base hydroxamic acid derivatives as dual JMJD3 and HDAC inhibitors. Bioorg Med Chem Lett. 2023 Oct 1;94:129466.. .

Molecular Formula	C₂₁H₃₀N₆O₂
Molecular Weight	398.50