2768426-49-7

2768426-49-7 structure

Name: FDW028
Chemical Name: FDW028
CAS Number: 2768426-49-7
Molecular Formula: C₂₂H₂₄N₆O
Molecular Weight: 388.47
Catalog: Signaling Pathways Autophagy Autophagy
Create Date: 2023-12-15 11:26:44
Modify Date: 2025-10-13 20:44:06
FDW028 a potent and highly selective FUT8 inhibitor. FUT8 exhibits potent anti-tumor activity by defucosylation and impelling lysosomal degradation of B7-H3 through the chaperone-mediated autophagy (CMA) pathway. FDW028 can be used for metastatic colorectal cancer (mCRC) research[1].

Name	FDW028

Description	FDW028 a potent and highly selective FUT8 inhibitor. FUT8 exhibits potent anti-tumor activity by defucosylation and impelling lysosomal degradation of B7-H3 through the chaperone-mediated autophagy (CMA) pathway. FDW028 can be used for metastatic colorectal cancer (mCRC) research[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Autophagy >> Autophagy
References	[1]. Wang M, et al. FDW028, a novel FUT8 inhibitor, impels lysosomal proteolysis of B7-H3 via chaperone-mediated autophagy pathway and exhibits potent efficacy against metastatic colorectal cancer. Cell Death Dis. 2023 Aug 3;14(8):495.

Molecular Formula	C₂₂H₂₄N₆O
Molecular Weight	388.47