2559759-40-7

2559759-40-7 structure

2559759-40-7 structure

Name: ABCG2-IN-1
Chemical Name: ABCG2-IN-1
CAS Number: 2559759-40-7
Molecular Formula: C₂₆H₃₆N₄O₄
Molecular Weight: 468.59
Catalog: Signaling Pathways Membrane Transporter/Ion Channel BCRP
Create Date: 2023-11-04 16:04:35
Modify Date: 2024-04-09 11:26:46
ABCG2-IN-1 (compound K2), a Ko143 analog, is an orally active ABCG2 inhibitor with an IC50 of 0.13 μM. ABCG2-IN-1 has favorable oral pharmacokinetic profiles in mice[1].

Name	ABCG2-IN-1

Description	ABCG2-IN-1 (compound K2), a Ko143 analog, is an orally active ABCG2 inhibitor with an IC50 of 0.13 μM. ABCG2-IN-1 has favorable oral pharmacokinetic profiles in mice[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Membrane Transporter/Ion Channel >> BCRP
Target	IC50: 0.13 μM (ABCG2)[1]
References	[1]. Junjie Zhu, et al. Metabolism-guided development of Ko143 analogs as ABCG2 inhibitors. Eur J Med Chem. 2023 Nov 5;259:115666.

Molecular Formula	C₂₆H₃₆N₄O₄
Molecular Weight	468.59