886755-63-1
886755-63-1 structure
- Name: Chs-111
- Chemical Name: CHS-111
- CAS Number: 886755-63-1
- Molecular Formula: C21H18N2O
- Molecular Weight: 314.38
- Catalog: Research Areas Others
- Create Date: 2024-02-02 06:59:21
- Modify Date: 2024-02-02 06:59:21
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CHS-111 is a benzyl indazole compound. CHS-111 inhibits superoxide anion (O(2)(-)) generation. CHS-111 reduces the fMLP-stimulated PLD activity (IC(50) 3.9±1.2μM). CHS-111 inhibits the interaction of PLD1 with ADP-ribosylation factor (Arf) 6 and Ras homology (Rho) A, and reduces the membrane recruitment of RhoA in fMLP-stimulated cells.
| Name | CHS-111 |
|---|
| Description | CHS-111 is a benzyl indazole compound. CHS-111 inhibits superoxide anion (O(2)(-)) generation. CHS-111 reduces the fMLP-stimulated PLD activity (IC(50) 3.9±1.2μM). CHS-111 inhibits the interaction of PLD1 with ADP-ribosylation factor (Arf) 6 and Ras homology (Rho) A, and reduces the membrane recruitment of RhoA in fMLP-stimulated cells. |
|---|---|
| References | 1. Chang LC, Huang TH, Chang CS, Tsai YR, Lin RH, Lee PW, Hsu MF, Huang LJ, Wang JP. Signaling mechanisms of inhibition of phospholipase D activation by CHS-111 in formyl peptide-stimulated neutrophils. Biochem Pharmacol. 2011 Jan 15;81(2):269-78. doi: 10.1016/j.bcp.2010.10.007. Epub 2010 Oct 20. PubMed PMID: 20965153. |
| Molecular Formula | C21H18N2O |
|---|---|
| Molecular Weight | 314.38 |