864082-23-5
864082-23-5 structure
- Name: GSK270822A
- Chemical Name: GSK270822A
- CAS Number: 864082-23-5
- Molecular Formula: C24H20N4O2
- Molecular Weight: 396.44
- Catalog: Signaling Pathways Cell Cycle/DNA Damage ROCK
- Create Date: 2023-12-22 23:29:06
- Modify Date: 2024-01-03 18:21:32
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GSK270822A is a selective ROCK1 inhibitor. GSK270822A exhibits IC50 of 9nM, 1100nM, 1550nM for ROCK1, RSK1, p70S6K, respectively.
| Name | GSK270822A |
|---|
| Description | GSK270822A is a selective ROCK1 inhibitor. GSK270822A exhibits IC50 of 9nM, 1100nM, 1550nM for ROCK1, RSK1, p70S6K, respectively. |
|---|---|
| In Vitro | GSK270822A inhibits rat aortic ring dilation with IC50 of 76nM[1]. |
| References | 1. Identification and Structure-Function Analysis of Subfamily Selective G Protein-Coupled Receptor Kinase Inhibitors. By Homan, Kristoff T.; Larimore, Kelly M.; Elkins, Jonathan M.; Szklarz, Marta; Knapp, Stefan; Tesmer, John J. G. From ACS Chemical Biology (2015), 10(1), 310-319. |
| Molecular Formula | C24H20N4O2 |
|---|---|
| Molecular Weight | 396.44 |