346689-77-8
346689-77-8 structure
- Name: XR-11576 HCl
- Chemical Name: XR-11576 HCl
- CAS Number: 346689-77-8
- Molecular Formula: C23H25ClN4O2
- Molecular Weight: 424.92
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Topoisomerase
- Create Date: 2024-04-06 15:43:30
- Modify Date: 2024-04-06 15:43:30
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XR-11576 HCl is a novel orally active dual topoisomerase I and II inhibitor with antitumor activity.
| Name | XR-11576 HCl |
|---|
| Description | XR-11576 HCl is a novel orally active dual topoisomerase I and II inhibitor with antitumor activity. |
|---|---|
| In Vitro | XR-11576 has an inhibitory effect (IC50=0.0121 µ M) on multidrug-resistant human non-small cell lung cancer cell line COR-L23 (COR-L23/R) overexpressing multidrug-resistant protein (MRP).[1] |
| References | 1. Vicker N, et al. Novel angular benzophenazines: dual topoisomerase I and topoisomerase II inhibitors as potential anticancer agents. J Med Chem. 2002;45(3):721-739. |
| Molecular Formula | C23H25ClN4O2 |
|---|---|
| Molecular Weight | 424.92 |