2187412-79-7
2187412-79-7 structure
- Name: DI-404
- Chemical Name: DI-404
- CAS Number: 2187412-79-7
- Molecular Formula: C35H45ClN6O6S
- Molecular Weight: 713.29
- Catalog: Signaling Pathways Metabolic Enzyme/Protease E1/E2/E3 Enzyme
- Create Date: 2023-12-26 23:20:53
- Modify Date: 2024-02-26 15:18:25
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DI-404 is a high-Affinity Peptidomimetic the DCN1-UBC12 Protein-Protein Interaction inhibitor (Kd= 6.9 nM). DI-404 effectively and selectively inhibits the neddylation of cullin 3 over other cullin members.
| Name | DI-404 |
|---|
| Description | DI-404 is a high-Affinity Peptidomimetic the DCN1-UBC12 Protein-Protein Interaction inhibitor (Kd= 6.9 nM). DI-404 effectively and selectively inhibits the neddylation of cullin 3 over other cullin members. |
|---|---|
| References | 1. ZHou HB, Zhou W, Zhou B, Liu L, Chern TR, Chinnaswamy K, Lu J, Bernard D, Yang C, Li S, Wang M, Stuckey JA, Sun Y, Wang S. High-Affinity Peptidomimetic Inhibitors of the DCN1-UBC12 Protein-Protein Interaction. J Med Chem. 2018 Feb 13. doi: 10.1021/acs.jmedchem.7b01455. [Epub ahead of print] PubMed PMID: 29438612. |
| Molecular Formula | C35H45ClN6O6S |
|---|---|
| Molecular Weight | 713.29 |