2131223-85-1
2131223-85-1 structure
- Name: YW2065
- Chemical Name: YW2065
- CAS Number: 2131223-85-1
- Molecular Formula: C20H15BrN4O
- Molecular Weight: 407.271
- Catalog: Research Areas Cancer
- Create Date:
- Modify Date:
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YW2065 has excellent anti-colorectal cancer effects in vitro and in vivo. YW2065 achieves its inhibitory activity for Wnt signaling by stabilizing Axin-1, a scaffolding protein that regulates proteasome degradation of β-catenin. Simultaneously, YW2065 also led to the activation of the tumor suppressor AMPK, providing an additional anticancer mechanism. In addition, YW2065 showed favorable pharmacokinetic properties without obvious toxicity.
| Name | YW2065 |
|---|
| Description | YW2065 has excellent anti-colorectal cancer effects in vitro and in vivo. YW2065 achieves its inhibitory activity for Wnt signaling by stabilizing Axin-1, a scaffolding protein that regulates proteasome degradation of β-catenin. Simultaneously, YW2065 also led to the activation of the tumor suppressor AMPK, providing an additional anticancer mechanism. In addition, YW2065 showed favorable pharmacokinetic properties without obvious toxicity. |
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| Molecular Formula | C20H15BrN4O |
|---|---|
| Molecular Weight | 407.271 |