85205-49-8

85205-49-8 structure

Name: noxiustoxin
Chemical Name: noxiustoxin
CAS Number: 85205-49-8
Molecular Formula: C₁₇₄H₂₈₆N₅₂O₅₄S₇
Molecular Weight: 4194.90364
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
Create Date: 2023-10-15 18:34:20
Modify Date: 2024-04-12 16:42:37
Noxiustoxin is a toxin from the venom of the Mexican scorpion Centruroides noxius which block voltage-dependent potassium channel (Kv1.3, IC50 = 360 nM), and calcium-activated potassium channel. Noxiustoxin plays an important role in neuroinflammatory disease[1][2].

Name	noxiustoxin

Description	Noxiustoxin is a toxin from the venom of the Mexican scorpion Centruroides noxius which block voltage-dependent potassium channel (Kv1.3, IC50 = 360 nM), and calcium-activated potassium channel. Noxiustoxin plays an important role in neuroinflammatory disease[1][2].
Related Catalog	Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
References	[1]. M Dauplais, et al. Determination of the Three-Dimensional Solution Structure of Noxiustoxin: Analysis of Structural Differences with Related Short-Chain Scorpion Toxins. Biochemistry.1995 Dec 26;34(51):16563-73. [2]. H H Valdivia, et al. Charybdotoxin and noxiustoxin, two homologous peptide inhibitors of the K+(Ca2+) channel. FEBS Lett. 1988 Jan 4;226(2):280-4.

Molecular Formula	C₁₇₄H₂₈₆N₅₂O₅₄S₇
Molecular Weight	4194.90364