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308359-57-1

308359-57-1 structure
308359-57-1 structure
  • Name: Zalypsis
  • Chemical Name: Zalypsis
  • CAS Number: 308359-57-1
  • Molecular Formula: C37H38F3N3O8
  • Molecular Weight: 709.71
  • Catalog: Signaling Pathways Apoptosis Apoptosis
  • Create Date: 2023-10-23 17:17:30
  • Modify Date: 2024-01-10 08:51:20
  • Zalypsis (PM00104) has anti-tumor activity. Zalypsis binds to DNA and shows cytotoxicity. Zalypsis inhibits cell cycle and transcription, and leads to double stranded DNA breaks[1][2].

Name Zalypsis
Description Zalypsis (PM00104) has anti-tumor activity. Zalypsis binds to DNA and shows cytotoxicity. Zalypsis inhibits cell cycle and transcription, and leads to double stranded DNA breaks[1][2].
Related Catalog
References

[1]. Duan Z, et al. Diverse cross-resistance phenotype to ET-743 and PM00104 in multi-drug resistant cell lines. Cancer Chemother Pharmacol. 2009 May;63(6):1121-9.  

[2]. Petek BJ, et al. PM00104 (Zalypsis®): a marine derived alkylating agent. Molecules. 2014 Aug 15;19(8):12328-35.  

Molecular Formula C37H38F3N3O8
Molecular Weight 709.71