433224-09-0

433224-09-0 structure

Name: TIE-2/VEGFR-2 kinase-IN-3
Chemical Name: TIE-2/VEGFR-2 kinase-IN-3
CAS Number: 433224-09-0
Molecular Formula: C₂₃H₁₇F₄N₅O₃S
Molecular Weight: 519.47
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK VEGFR
Create Date: 2023-10-20 12:02:39
Modify Date: 2024-04-05 23:15:53
TIE-2/VEGFR-2 kinase-IN-3, benzimidazole, is a potent TIE-2 and VEGFR-2 tyrosine kinase receptors inhibitors with IC50 values of 6.9 nM and 3.5 nM, respectively. TIE-2/VEGFR-2 kinase-IN-3 can be used for the research of angiogenesis[1].

Name	TIE-2/VEGFR-2 kinase-IN-3

Description	TIE-2/VEGFR-2 kinase-IN-3, benzimidazole, is a potent TIE-2 and VEGFR-2 tyrosine kinase receptors inhibitors with IC50 values of 6.9 nM and 3.5 nM, respectively. TIE-2/VEGFR-2 kinase-IN-3 can be used for the research of angiogenesis[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR
Target	Tie2:6.9 nM (IC50) VEGFR-2:3.5 nM (IC50)
References	[1]. Hasegawa M, et al. Discovery of novel benzimidazoles as potent inhibitors of TIE-2 and VEGFR-2 tyrosine kinase receptors. J Med Chem. 2007 Sep 6;50(18):4453-70.

Molecular Formula	C₂₃H₁₇F₄N₅O₃S
Molecular Weight	519.47