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2760612-63-1

2760612-63-1 structure
2760612-63-1 structure
  • Name: Skp2 inhibitor 1
  • Chemical Name: Skp2 inhibitor 1
  • CAS Number: 2760612-63-1
  • Molecular Formula: C23H23ClN4O
  • Molecular Weight: 406.91
  • Catalog: Signaling Pathways Metabolic Enzyme/Protease E1/E2/E3 Enzyme
  • Create Date: 2023-11-17 21:01:16
  • Modify Date: 2024-01-05 10:37:05
  • Skp2 inhibitor 1 (compound 14i) is a potent and selective Skp2 inhibitor against the Skp2-Cks1 interaction with an IC50 of 2.8 μM. Skp inhibitor 1 exhibits anticancer activity[1].

Name Skp2 inhibitor 1
Description Skp2 inhibitor 1 (compound 14i) is a potent and selective Skp2 inhibitor against the Skp2-Cks1 interaction with an IC50 of 2.8 μM. Skp inhibitor 1 exhibits anticancer activity[1].
Related Catalog
Target

Growth arrest-specific protein 6(Gas6)-Cell Cyclin Kinase Subunit 1(Cks1) [1]IC50:2.8 μM(Growth arrest-specific protein 6,Gas6; Cell Cyclin Kinase Subunit 1,Cks1)[1]

References

[1]. Zhang K, et al. Discovery of Novel 1,3-Diphenylpyrazine Derivatives as Potent S-Phase Kinase-Associated Protein 2 (Skp2) Inhibitors for the Treatment of Cancer. J Med Chem. 2023 Jun 8;66(11):7221-7242.  

Molecular Formula C23H23ClN4O
Molecular Weight 406.91