2918281-79-3

2918281-79-3 structure

Name: RET-IN-22
Chemical Name: RET-IN-22
CAS Number: 2918281-79-3
Molecular Formula: C₂₉H₃₁F₃N₆O₄
Molecular Weight: 584.59
Catalog: Research Areas Cancer
Create Date: 2023-11-25 11:50:54
Modify Date: 2024-01-26 22:44:45
RET-IN-22 (compound 17b) is a potent, selective and orally active RET inhibitor with an IC50 of 20.9 nM and 18.3 nM for wild-type RET and RET-V804M, respectively. RET-IN-22 shows highly selective profile to most kinases, especially to EGFR and VEGFR2. RET-IN-22 has anticancer effects[1].

Name	RET-IN-22

Description	RET-IN-22 (compound 17b) is a potent, selective and orally active RET inhibitor with an IC50 of 20.9 nM and 18.3 nM for wild-type RET and RET-V804M, respectively. RET-IN-22 shows highly selective profile to most kinases, especially to EGFR and VEGFR2. RET-IN-22 has anticancer effects[1].
Related Catalog	Research Areas >> Cancer
Target	IC50: 20.9 nM (wild-type RET) and 18.3 nM (RET-V804M)[1]
References	[1]. Kaifu Wu, et al. Discovery of 3,5-diaryl-1H-pyrazol-based ureas as potent RET inhibitors. Eur J Med Chem. 2023 May 5;251:115237.

Molecular Formula	C₂₉H₃₁F₃N₆O₄
Molecular Weight	584.59