742058-34-0

742058-34-0 structure

Name: Nurr1 agonist 2
Chemical Name: Nurr1 agonist 2
CAS Number: 742058-34-0
Molecular Formula: C₁₈H₁₄O₃S
Molecular Weight: 310.37
Catalog: Research Areas Others
Create Date: 2023-10-20 19:22:39
Modify Date: 2024-04-05 21:00:01
Nurr1 agonist 3 (Compound 7) is a Nurr1 agonist (EC50: 0.07 μM). Nurr1 agonist 3 binds to the recombinant Nurr1 ligand binding domain (LBD) with a Kd value of 0.14 μM. Nurr1 agonist 3 increases the Nurr1-regulated genes tyrosine hydroxylase (TH) and vesicular amino acid transporter 2 (VMAT2) mRNA expression[1].

Name	Nurr1 agonist 2

Description	Nurr1 agonist 3 (Compound 7) is a Nurr1 agonist (EC50: 0.07 μM). Nurr1 agonist 3 binds to the recombinant Nurr1 ligand binding domain (LBD) with a Kd value of 0.14 μM. Nurr1 agonist 3 increases the Nurr1-regulated genes tyrosine hydroxylase (TH) and vesicular amino acid transporter 2 (VMAT2) mRNA expression[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Ballarotto M, et al.De Novo Design of Nurr1 Agonists via Fragment-Augmented Generative Deep Learning in Low-Data Regime. J Med Chem. 2023 Jun 22;66(12):8170-8177.

Molecular Formula	C₁₈H₁₄O₃S
Molecular Weight	310.37