1239578-80-3

1239578-80-3 structure

Name: NP-1815-PX sodium
Chemical Name: NP-1815-PX sodium
CAS Number: 1239578-80-3
Molecular Formula: C₂₁H₁₃N₄NaO₃S
Molecular Weight: 424.41
Catalog: Signaling Pathways Membrane Transporter/Ion Channel P2X Receptor
Create Date: 2023-09-19 13:58:27
Modify Date: 2024-02-01 14:06:07
NP-1815-PX sodium is a potent and selective P2X4R antagonist. NP-1815-PX sodium has anti-inflammatory activity, and can relieve pain in chronic pain models. NP-1815-PX sodium also inhibits guinea pig tracheal/bronchial smooth muscle (TSM and BSM) contractions[1][2][3].

Name	NP-1815-PX sodium

Description	NP-1815-PX sodium is a potent and selective P2X4R antagonist. NP-1815-PX sodium has anti-inflammatory activity, and can relieve pain in chronic pain models. NP-1815-PX sodium also inhibits guinea pig tracheal/bronchial smooth muscle (TSM and BSM) contractions[1][2][3].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Membrane Transporter/Ion Channel >> P2X Receptor Research Areas >> Neurological Disease
References	[1]. Matsumura Y, et al. A novel P2X4 receptor-selective antagonist produces anti-allodynic effect in a mouse model of herpetic pain. Sci Rep. 2016 Aug 31;6:32461. [2]. Obara K, et al. Effects of NP-1815-PX, a P2X4 Receptor Antagonist, on Contractions in Guinea Pig Tracheal and Bronchial Smooth Muscles. Biol Pharm Bull. 2022;45(8):1158-1165. [3]. D'Antongiovanni V, et al. Anti-inflammatory Effects of Novel P2X4 Receptor Antagonists, NC-2600 and NP-1815-PX, in a Murine Model of Colitis. Inflammation. 2022 Aug;45(4):1829-1847.

Molecular Formula	C₂₁H₁₃N₄NaO₃S
Molecular Weight	424.41