269745-22-4

269745-22-4 structure

Name: Maurocalcine
Chemical Name: Maurocalcine
CAS Number: 269745-22-4
Molecular Formula: C₁₅₆H₂₇₀N₅₆O₄₆S₆
Molecular Weight: 3858.55
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Calcium Channel
Create Date: 2023-11-07 18:18:29
Modify Date: 2025-08-25 11:57:02
Maurocalcine is an agonist of ryanodine receptor (RyR) channel types 1, 2 and 3 with cellular permeability. Maurocalcine induces [3H]ryanodine binding on RyR1 with an EC50 value of 2558 nM. Maurocalcine exhibits a apparent affinity of 14 nM for RyR2. Maurocalcine can be applied to in vivo cell tracking or other cell imaging techniques[1][2][3].

Name	Maurocalcine

Description	Maurocalcine is an agonist of ryanodine receptor (RyR) channel types 1, 2 and 3 with cellular permeability. Maurocalcine induces [3H]ryanodine binding on RyR1 with an EC50 value of 2558 nM. Maurocalcine exhibits a apparent affinity of 14 nM for RyR2. Maurocalcine can be applied to in vivo cell tracking or other cell imaging techniques[1][2][3].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Others
References	[1]. De Waard S, et al. Maurocalcin and its analog MCaE12A facilitate Ca2+ mobilization in cardiomyocytes. Biochem J. 2020 Oct 30;477(20):3985-3999. [2]. Altafaj X, et al. Maurocalcine interacts with the cardiac ryanodine receptor without inducing channel modification. Biochem J. 2007 Sep 1;406(2):309-15. [3]. Boisseau S, et al. Cell penetration properties of maurocalcine, a natural venom peptide active on the intracellular ryanodine receptor. Biochim Biophys Acta. 2006 Mar;1758(3):308-19.

Molecular Formula	C₁₅₆H₂₇₀N₅₆O₄₆S₆
Molecular Weight	3858.55