2648334-36-3

2648334-36-3 structure

Name: HIF-2α-IN-9
Chemical Name: HIF-2α-IN-9
CAS Number: 2648334-36-3
Molecular Formula: C₁₂H₁₃F₅O₄S₂
Molecular Weight: 380.35
Catalog: Signaling Pathways Metabolic Enzyme/Protease HIF/HIF Prolyl-Hydroxylase
Create Date: 2023-11-11 14:25:51
Modify Date: 2024-01-11 21:27:05
HIF-2α-IN-9 (compound 35r) is an inhibitor ofHIF-2α. HIF-2α-IN-9 inhibits VEGF-A (IC50=305 nM), and regulates growth-promoting genes in tumor cells, reactivates macrophage-mediated tumor immunity[1].

Name	HIF-2α-IN-9

Description	HIF-2α-IN-9 (compound 35r) is an inhibitor ofHIF-2α. HIF-2α-IN-9 inhibits VEGF-A (IC50=305 nM), and regulates growth-promoting genes in tumor cells, reactivates macrophage-mediated tumor immunity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase
Target	HIF-2α[1]
References	[1]. Buchstaller H P, et al. Discovery of Cycloalkyl [c] thiophenes as Novel Scaffolds for Hypoxia-Inducible Factor-2伪 Inhibitors[J]. Journal of Medicinal Chemistry, 2023..

Molecular Formula	C₁₂H₁₃F₅O₄S₂
Molecular Weight	380.35