2658488-68-5

2658488-68-5 structure

Name: FGFR-IN-11
Chemical Name: FGFR-IN-11
CAS Number: 2658488-68-5
Molecular Formula: C₂₈H₂₉ClN₄O₄
Molecular Weight: 521.01
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK FGFR
Create Date: 2023-09-27 21:05:15
Modify Date: 2024-01-12 19:16:20
FGFR-IN-11 (compound I-5) is an orally active and covalent FGFR inhibitor with IC50 values of 9.9 nM (FGFR1), 3.1 nM (FGFR2), 16 nM (FGFR3), and 1.8 nM (FGFR4), respectively. FGFR-IN-11 inhibits multiple cancer cell proliferation with nanomolar activity. FGFR-IN-11 inhibits tumor growth significantly in xenograft mice models[1].

Name	FGFR-IN-11

Description	FGFR-IN-11 (compound I-5) is an orally active and covalent FGFR inhibitor with IC50 values of 9.9 nM (FGFR1), 3.1 nM (FGFR2), 16 nM (FGFR3), and 1.8 nM (FGFR4), respectively. FGFR-IN-11 inhibits multiple cancer cell proliferation with nanomolar activity. FGFR-IN-11 inhibits tumor growth significantly in xenograft mice models[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FGFR
Target	FGFR1:9.9 nM (IC50) FGFR2:3.1 nM (IC50) FGFR3:16 nM (IC50) FGFR4:1.8 nM (IC50)
References	[1]. Hu S, et al. Discovery and Structural Optimization of Novel Quinolone Derivatives as Potent Irreversible Pan-Fibroblast Growth Factor Receptor Inhibitors for Treating Solid Tumors. J Med Chem. 2023 Jul 13;66(13):8858-8875.

Molecular Formula	C₂₈H₂₉ClN₄O₄
Molecular Weight	521.01