2227366-66-5

2227366-66-5 structure

Name: BT1718
Chemical Name: BT1718
CAS Number: 2227366-66-5
Molecular Formula: C₁₅₉H₂₁₈ClN₃₁O₄₇S₅
Molecular Weight: 3511.39
Catalog: Signaling Pathways Metabolic Enzyme/Protease MMP
Create Date: 2023-10-08 16:20:16
Modify Date: 2024-01-11 13:39:26
BT1718 is a bicyclic anticancer peptide targeting MT1-MMP. BT1718 uses MT1-MMP to target tumors and promote delivery of the cytotoxic payload Mertansine (HY-19792). BT1718 is a bicycle toxin conjugate with a KD value of 3 nM. MT1-MMP is overexpressed in a variety of advanced solid tumors, including triple-negative breast cancer (TNBC), non-small cell lung cancer[1][2].

Name	BT1718

Description	BT1718 is a bicyclic anticancer peptide targeting MT1-MMP. BT1718 uses MT1-MMP to target tumors and promote delivery of the cytotoxic payload Mertansine (HY-19792). BT1718 is a bicycle toxin conjugate with a KD value of 3 nM. MT1-MMP is overexpressed in a variety of advanced solid tumors, including triple-negative breast cancer (TNBC), non-small cell lung cancer[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> MMP
Target	MMP14
References	[1]. Gowland C, et al. Development of a LC-MS/MS method for the quantification of toxic payload DM1 cleaved from BT1718 in a Phase I study. Bioanalysis. 2021 Jan;13(2):101-113. [2]. Helen Harrison, et al. BT1718, a novel bicyclic peptide-maytansinoid conjugate targeting MT1-MMP for the treatment of solid tumors: Design of bicyclic peptide and linker selection.Cancer Research 77(13 Supplement) 2017 July:5144-5144

Molecular Formula	C₁₅₉H₂₁₈ClN₃₁O₄₇S₅
Molecular Weight	3511.39