2407854-18-4

2407854-18-4 structure
2407854-18-4 structure
  • Name: BMS-502
  • Chemical Name: BMS-502
  • CAS Number: 2407854-18-4
  • Molecular Formula: C27H22F2N6O3
  • Molecular Weight: 516.50
  • Catalog: Research Areas Inflammation/Immunology
  • Create Date: 2023-10-03 16:22:28
  • Modify Date: 2025-08-25 10:59:11
  • BMS-502 (Compound 22) is a potent dual inhibitor of diacylglycerol kinase (DGK) α and ζ with IC50 of 4.6 nM and 2.1 nM. BMS-502 enhanced T cell immune responses in mice. BMS-502 can be used in tumor immunity related research[1].

Name BMS-502
Description BMS-502 (Compound 22) is a potent dual inhibitor of diacylglycerol kinase (DGK) α and ζ with IC50 of 4.6 nM and 2.1 nM. BMS-502 enhanced T cell immune responses in mice. BMS-502 can be used in tumor immunity related research[1].
Related Catalog
Target

IC50: 4.6 nM (DGK α), 2.1nM (DGK ζ)[1].

References

[1]. Chupak L, et al. Discovery of Potent, Dual-Inhibitors of Diacylglycerol Kinases Alpha and Zeta Guided by Phenotypic Optimization. ACS Med Chem Lett. 2023 Jun 12;14(7):929-935.  

Molecular Formula C27H22F2N6O3
Molecular Weight 516.50
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