2089314-64-5

2089314-64-5 structure

Name: AOH1996
Chemical Name: aoh1996
CAS Number: 2089314-64-5
Molecular Formula: C₂₆H₂₂N₂O₄
Molecular Weight: 426.46
Catalog: Research Areas Cancer
Create Date: 2023-09-18 17:57:01
Modify Date: 2024-01-03 20:00:50
AOH1996 is an orally active ligand of replisome component PCNA (Proliferating cell nuclear antigen), targeting to transcription-replication conflict (TRC). AOH1996 stabilizes the interaction of PCNA and RNA polymerase II, causing proteasome-dependent degradation of rpb1 and lethal DNA damages. AOH1996 also interferes the interaction of PCNA and its binding proteins, leading to DNA replication stress and inducing apoptosis. AOH1996 exerts synergistic effect with DNA damage agents, to inhibit tumor cells[1][2].

Name	aoh1996

Description	AOH1996 is an orally active ligand of replisome component PCNA (Proliferating cell nuclear antigen), targeting to transcription-replication conflict (TRC). AOH1996 stabilizes the interaction of PCNA and RNA polymerase II, causing proteasome-dependent degradation of rpb1 and lethal DNA damages. AOH1996 also interferes the interaction of PCNA and its binding proteins, leading to DNA replication stress and inducing apoptosis. AOH1996 exerts synergistic effect with DNA damage agents, to inhibit tumor cells[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
Target	PCNA, Proliferating cell nuclear antigen[1][2]
References	[1]. Gu L, et al. Pharmacological targeting of transcription-replication conflict leads to anti-cancer efficacy with minimal side effects in preclinical models[J]. Cancer Research, 2021, 81(13_Supplement): 1269-1269.