1794754-60-1

1794754-60-1 structure

Name: Sulisobenzone
Chemical Name: rmmxlenwkuumay-zencxjlosa-n
CAS Number: 1794754-60-1
Molecular Formula: C₃₃H₂₃D₇N₄O₂
Molecular Weight: 521.66
Catalog: Research Areas Cardiovascular Disease
Create Date: 2023-08-31 19:18:14
Modify Date: 2024-01-13 23:40:50
Telmisartan-d7 (BIBR 277-d7) is a deuterium labeled Telmisartan (HY-13955). Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC50 of 9.2 nM.

Name	rmmxlenwkuumay-zencxjlosa-n

Description	Telmisartan-d7 (BIBR 277-d7) is a deuterium labeled Telmisartan (HY-13955). Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC50 of 9.2 nM.
Related Catalog	Research Areas >> Cardiovascular Disease
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-246. [2]. Maillard MP, et al. In vitro and in vivo characterization of the activity of telmisartan: an insurmountable angiotensin II receptor antagonist. J Pharmacol Exp Ther. 2002 Sep;302(3):1089-95. [3]. Xuan H, et al. Inhibition or deletion of angiotensin II type 1 receptor suppresses elastase-induced experimental abdominal aortic aneurysms. J Vasc Surg. 2017 Apr 20. pii: S0741-5214(17)30100-3. [4]. Torika N, et al. Intranasal telmisartan ameliorates brain pathology in five familial Alzheimer's disease mice. Brain Behav Immun. 2017 Apr 3. [5]. Aswar U, et al. Telmisartan attenuates diabetes induced depression in rats. Pharmacol Rep. 2017 Apr;69(2):358-364. [6]. Fujihara S, et al. The angiotensin II type 1 receptor antagonist telmisartan inhibits cell proliferation and tumor growth of esophageal adenocarcinoma via the AMPKα/mTOR pathway in vitro and in vivo. Oncotarget. 2017 Jan 31;8(5):8536-8549.

Molecular Formula	C₃₃H₂₃D₇N₄O₂
Molecular Weight	521.66
Appearance	Solid \| White to Light Yellow
Water Solubility	Acetonitrile (Slightly, Heated, Sonicated), DMSO (Slightly, Heated)