1414348-52-9

1414348-52-9 structure
1414348-52-9 structure
  • Name: Rolitetracycline (Technical Grade)
  • Chemical Name: D-Serine-2,3,3-d3
  • CAS Number: 1414348-52-9
  • Molecular Formula: C3H4D3NO3
  • Molecular Weight: 108.11
  • Catalog: Research Areas Neurological Disease
  • Create Date: 2023-09-11 11:46:40
  • Modify Date: 2026-07-16 08:25:46
  • D-Serine-d3 ((R)-Serine-d3) is a deuterium labeled D-Serine (HY-100808). D-Serine ((R)-Serine), an endogenous amino acid involved in glia-synapse interactions that has unique neurotransmitter characteristics, is a potent co-agonist at the NMDA glutamate receptor. D-Serinee has a cardinal modulatory role in major NMDAR-dependent processes including NMDAR-mediated neurotransmission, neurotoxicity, synaptic plasticity, and cell migration[1][2][3].

Name D-Serine-2,3,3-d3
Description D-Serine-d3 ((R)-Serine-d3) is a deuterium labeled D-Serine (HY-100808). D-Serine ((R)-Serine), an endogenous amino acid involved in glia-synapse interactions that has unique neurotransmitter characteristics, is a potent co-agonist at the NMDA glutamate receptor. D-Serinee has a cardinal modulatory role in major NMDAR-dependent processes including NMDAR-mediated neurotransmission, neurotoxicity, synaptic plasticity, and cell migration[1][2][3].
Related Catalog
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-246.  

[2]. Andrea R. Durrant, et al. D-Serine in Neuropsychiatric Disorders: New Advances.

[3]. MacKay MB, et al. D-Serine: Potential Therapeutic Agent and/or Biomarker in Schizophrenia and Depression Front Psychiatry. 2019 Feb 6;10:25.  

[4]. Dai X, et al. D-Serine made by serine racemase in Drosophila intestine plays a physiological role in sleep. Nat Commun. 2019 May 7;10(1):1986.  

[5]. Suwandhi L, et al. Chronic d-serine supplementation impairs insulin secretion. Mol Metab. 2018 Oct;16:191-202.  

Melting Point >208°C (dec.)
Molecular Formula C3H4D3NO3
Molecular Weight 108.11
Appearance Solid | White to Off-White
Storage condition Room Temperature, under inert atmosphere
Water Solubility Aqueous Acid (Slightly), Water (Slightly)
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