2377301-45-4
2377301-45-4 structure
- Name: Tubulin polymerization-IN-12
- Chemical Name: Tubulin polymerization-IN-12
- CAS Number: 2377301-45-4
- Molecular Formula: C23H23N5O6
- Molecular Weight: 465.46
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Microtubule/Tubulin
- Create Date: 2023-07-08 18:32:03
- Modify Date: 2024-04-11 21:45:54
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Tubulin polymerization-IN-12 is a tubulin polymerization inhibitor (IC50=0.75 μM). Tubulin polymerization-IN-12 arrests cell cycle at G2/M phase, and exhibits cytotoxicity against cancer cells[1].
| Name | Tubulin polymerization-IN-12 |
|---|
| Description | Tubulin polymerization-IN-12 is a tubulin polymerization inhibitor (IC50=0.75 μM). Tubulin polymerization-IN-12 arrests cell cycle at G2/M phase, and exhibits cytotoxicity against cancer cells[1]. |
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| Related Catalog | |
| In Vitro | Tubulin polymerization-IN-12 (compound 6) 对正常人胚胎肾细胞 HEK-293 显示出细胞毒性，IC50 值为 29.94 μM[1]。 Tubulin polymerization-IN-12 (compound 26) 抑制癌细胞的 IC50 分别为 1.02 μM (A549)，0.75 μM (HeLa)，10.91 μM (HCT116)，和 29.94 μM (HEK293)[2]。 Tubulin polymerization-IN-12 (1 μM, 2 μM, 10 μM; 6 h) 抑制 HeLa 细胞中的微管蛋白表达，在 10 μM 时抑制率为 42%[2]。 Tubulin polymerization-IN-12 (0.75 μM-3 μM；24 h) 使 HeLa 细胞的细胞周期停滞在 G2/M 期[2]。 Immunofluorescence[2] Cell Line: HeLa cells Concentration: 1 μM, 2 μM Incubation Time: 6 hours Result: Dose-dependently decreased the level of α and β tubulin. Cell Cycle Analysis[2] Cell Line: HeLa cells Concentration: 0.75 μM, 1.5 μM, 3 μM Incubation Time: 24 hours Result: Demonstrated 15.03% (0.75 μM), 20.04% (1.50 μM), and 33.47% (3.00 μM) of cell accumulation in G2/M phase. |
| References |
| Molecular Formula | C23H23N5O6 |
|---|---|
| Molecular Weight | 465.46 |