2641998-63-0

2641998-63-0 structure

Name: RMC-6291
Chemical Name: RMC-6291
CAS Number: 2641998-63-0
Molecular Formula: C₅₅H₇₈FN₉O₈
Molecular Weight: 1012.26
Catalog: Signaling Pathways GPCR/G Protein Ras
Create Date: 2023-05-31 14:14:21
Modify Date: 2024-01-03 18:07:57
RMC-6291 is an orally active and covalent inhibitor of KRASG12C(ON). RMC-6291 forms a tri-complex within tumor cells between KRASG12C(ON) and cyclophilin A (CypA). Thus, RMC-6291 prevents KRASG12C(ON) from signaling via steric blockade of RAS effector binding. RMC-6291 elicits deep and durable suppression on RAS pathway activity in KRASG12C tumor models[1].

Name	RMC-6291

Description	RMC-6291 is an orally active and covalent inhibitor of KRASG12C(ON). RMC-6291 forms a tri-complex within tumor cells between KRASG12C(ON) and cyclophilin A (CypA). Thus, RMC-6291 prevents KRASG12C(ON) from signaling via steric blockade of RAS effector binding. RMC-6291 elicits deep and durable suppression on RAS pathway activity in KRASG12C tumor models[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> Ras
Target	KRAS(G12C)
References	[1]. Nichols R J, et al. RMC-6291, a next-generation tri-complex KRASG12C (ON) inhibitor, outperforms KRASG12C (OFF) inhibitors in preclinical models of KRASG12C cancers[J]. Cancer Research, 2022, 82(12_Supplement): 3595-3595.

Molecular Formula	C₅₅H₇₈FN₉O₈
Molecular Weight	1012.26