642072-48-8
642072-48-8 structure
- Name: MEL24
- Chemical Name: MEL24
- CAS Number: 642072-48-8
- Molecular Formula: C17H18N4O3
- Molecular Weight: 326.35
- Catalog: Research Areas Cancer
- Create Date: 2023-06-23 18:33:15
- Modify Date: 2025-08-22 07:23:09
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MEL24 is an Mdm2 E3 ligase inhibitor that reduces cell survival and increases sensitivity to DNA damaging agents in a p53-dependent manner for in vitro antitumor studies[1].
| Name | MEL24 |
|---|
| Description | MEL24 is an Mdm2 E3 ligase inhibitor that reduces cell survival and increases sensitivity to DNA damaging agents in a p53-dependent manner for in vitro antitumor studies[1]. |
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| Related Catalog | |
| In Vitro | MEL24 作用于 293T 细胞，ED50 值为 9.2 μM[1]。 MEL24（15 μM，6 小时）增加 Mdm2、p53 和 MdmX 的水平并激活 p53，抑制 HCT116 细胞（p53 野生型）中内源性 MdmX 的降解[1]。 |
| References |
| Molecular Formula | C17H18N4O3 |
|---|---|
| Molecular Weight | 326.35 |