1310809-17-6
1310809-17-6 structure
- Name: JHDM-IN-1
- Chemical Name: JHDM-IN-1
- CAS Number: 1310809-17-6
- Molecular Formula: C27H29N3O6
- Molecular Weight: 491.54
- Catalog: Signaling Pathways Epigenetics Histone Demethylase
- Create Date: 2023-06-04 10:33:45
- Modify Date: 2024-01-30 18:29:24
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JHDM-IN-1 (Compound 1) is a Jumonji C domain-containing HDMs (JHDM) inhibitor with IC50s of 3.4, 4.3, 5.9, 10 and 43 μM against JMJD2C, JMJD2A, JMJD2E, PHF8 and JMJD3, respectively[1].
| Name | JHDM-IN-1 |
|---|
| Description | JHDM-IN-1 (Compound 1) is a Jumonji C domain-containing HDMs (JHDM) inhibitor with IC50s of 3.4, 4.3, 5.9, 10 and 43 μM against JMJD2C, JMJD2A, JMJD2E, PHF8 and JMJD3, respectively[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 3.4 μM (JMJD2C), 4.3 μM (JMJD2A), 5.9 μM (JMJD2E), 10 μM (PHF8), 22 μM (FIH), 31 μM (PHD3), 43 μM (JMJD3), 54 μM (PHD1), 83 μM (PHD2), 620 μM (LSD1)[1] |
| In Vitro | JHDM-IN-1 (Compound 1) 抑制 FIH、PHD3、PHD1、PHD2 和 LSD1 的 IC50 分别为 22、31、54、83 和 620 μM[1]。 JHDM-IN-1 (0-100 μM) 处理 48 h 后对 KYSE150 细胞生长无抑制作用[1]。 |
| References |
| Molecular Formula | C27H29N3O6 |
|---|---|
| Molecular Weight | 491.54 |