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1310809-17-6

1310809-17-6 structure

1310809-17-6 structure

Name: JHDM-IN-1
Chemical Name: JHDM-IN-1
CAS Number: 1310809-17-6
Molecular Formula: C₂₇H₂₉N₃O₆
Molecular Weight: 491.54
Catalog: Signaling Pathways Epigenetics Histone Demethylase
Create Date: 2023-06-04 10:33:45
Modify Date: 2024-01-30 18:29:24
JHDM-IN-1 (Compound 1) is a Jumonji C domain-containing HDMs (JHDM) inhibitor with IC50s of 3.4, 4.3, 5.9, 10 and 43 μM against JMJD2C, JMJD2A, JMJD2E, PHF8 and JMJD3, respectively[1].

Name	JHDM-IN-1

Description	JHDM-IN-1 (Compound 1) is a Jumonji C domain-containing HDMs (JHDM) inhibitor with IC50s of 3.4, 4.3, 5.9, 10 and 43 μM against JMJD2C, JMJD2A, JMJD2E, PHF8 and JMJD3, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Histone Demethylase
Target	IC50: 3.4 μM (JMJD2C), 4.3 μM (JMJD2A), 5.9 μM (JMJD2E), 10 μM (PHF8), 22 μM (FIH), 31 μM (PHD3), 43 μM (JMJD3), 54 μM (PHD1), 83 μM (PHD2), 620 μM (LSD1)[1]
In Vitro	JHDM-IN-1 (Compound 1) 抑制 FIH、PHD3、PHD1、PHD2 和 LSD1 的 IC50 分别为 22、31、54、83 和 620 μM[1]。 JHDM-IN-1 (0-100 μM) 处理 48 h 后对 KYSE150 细胞生长无抑制作用[1]。
References	[1]. Luo X, et al. A selective inhibitor and probe of the cellular functions of Jumonji C domain-containing histone demethylases. J Am Chem Soc. 2011 Jun 22;133(24):9451-6.

Molecular Formula	C₂₇H₂₉N₃O₆
Molecular Weight	491.54

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