2901064-06-8

2901064-06-8 structure

Name: Antifungal agent 52
Chemical Name: Antifungal agent 52
CAS Number: 2901064-06-8
Molecular Formula: C₂₅H₁₉BrClFN₆O
Molecular Weight: 553.81
Catalog: Signaling Pathways Anti-infection Fungal
Create Date: 2023-06-18 10:59:55
Modify Date: 2024-02-13 06:16:42
Antifungal agent 52 (compound 6c) is a tetrazole derivative. Antifungal agent 52 inhibits the synthesis of Ergosterol (HY-N0181). Antifungal agent 52 exhibit a significant antifungal activity against Candida albicans. Antifungal agent 52 affects C. albicans sessile cell membrane permeabilization[1].

Name	Antifungal agent 52

Description	Antifungal agent 52 (compound 6c) is a tetrazole derivative. Antifungal agent 52 inhibits the synthesis of Ergosterol (HY-N0181). Antifungal agent 52 exhibit a significant antifungal activity against Candida albicans. Antifungal agent 52 affects C. albicans sessile cell membrane permeabilization[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal
In Vitro	Antifungal agent 52 (compound 6c) (16 μg/mL, 18 h) 处理的细胞进入G0/G1期（代谢状态/细胞增殖）以维持子细胞[1]。 Antifungal agent 52 在 >64 μg/mL 时显示出显着毒性，并且对口腔癌细胞系 TR146 没有毒性[1]。
References	[1]. Staniszewska M, et al. Tetrazole derivatives bearing benzodiazepine moiety-synthesis and action mode against virulence of Candida albicans. Eur J Med Chem. 2022 Feb 15;230:114060.

Molecular Formula	C₂₅H₁₉BrClFN₆O
Molecular Weight	553.81