2446645-88-9

2446645-88-9 structure

Name: (Aminooxy)acetamide-Val-Cit-PAB-MMAE
Chemical Name: (Aminooxy)acetamide-Val-Cit-PAB-MMAE
CAS Number: 2446645-88-9
Molecular Formula: C₆₀H₉₇N₁₁O₁₄
Molecular Weight: 1196.48
Catalog: Research Areas Cancer
Create Date: 2023-07-18 10:51:15
Modify Date: 2025-09-10 18:28:34
(Aminooxy)acetamide-Val-Cit-PAB-MMAE (MMAE 5) is an intermediate used in the synthetic preparation of drug-linker conjugates for ADC. (Aminooxy)acetamide-Val-Cit-PAB-MMAE is conjugated to polyamide via oxime bond formation to form MMAE polyamide conjugate. Then MMAE polyamide conjugate can be conjugated to Trastuzumab, to make ADC[1].

Name	(Aminooxy)acetamide-Val-Cit-PAB-MMAE

Description	(Aminooxy)acetamide-Val-Cit-PAB-MMAE (MMAE 5) is an intermediate used in the synthetic preparation of drug-linker conjugates for ADC. (Aminooxy)acetamide-Val-Cit-PAB-MMAE is conjugated to polyamide via oxime bond formation to form MMAE polyamide conjugate. Then MMAE polyamide conjugate can be conjugated to Trastuzumab, to make ADC[1].
Related Catalog	Research Areas >> Cancer
References	[1]. Ouberai Myriam, et al. Preparation of antibody-drug conjugates using polymers and crosslinkers. World Intellectual Property Organization, WO2020128488 A1. 2020-06-25.

Molecular Formula	C₆₀H₉₇N₁₁O₁₄
Molecular Weight	1196.48