959662-26-1
959662-26-1 structure
- Name: 7-Hydroxyneolamellarin A
- Chemical Name: 7-Hydroxyneolamellarin A
- CAS Number: 959662-26-1
- Molecular Formula: C24H19NO5
- Molecular Weight: 401.41
- Catalog: Signaling Pathways Metabolic Enzyme/Protease HIF/HIF Prolyl-Hydroxylase
- Create Date: 2023-06-24 19:43:22
- Modify Date: 2024-02-04 08:30:56
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7-Hydroxyneolamellarin A is a natural product that could be derived from sponge Dendrilla nigra. 7-Hydroxyneolamellarin A is a potent hypoxia-inducible factor-1α (HIF-1α) inhibitor. 7-Hydroxyneolamellarin A attenuates the accumulation of hypoxia-inducible factor-1α (HIF-1α) protein and inhibits vascular epidermal growth factor (VEGF) transcriptional activity. 7-Hydroxyneolamellarin A can be used in research of cancer[1].
| Name | 7-Hydroxyneolamellarin A |
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| Description | 7-Hydroxyneolamellarin A is a natural product that could be derived from sponge Dendrilla nigra. 7-Hydroxyneolamellarin A is a potent hypoxia-inducible factor-1α (HIF-1α) inhibitor. 7-Hydroxyneolamellarin A attenuates the accumulation of hypoxia-inducible factor-1α (HIF-1α) protein and inhibits vascular epidermal growth factor (VEGF) transcriptional activity. 7-Hydroxyneolamellarin A can be used in research of cancer[1]. |
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| Related Catalog | |
| In Vitro | 7-Hydroxyneolamellarin A (0-150 μM; 12 h; Hela 细胞, MCF-7 细胞和 4T1 细胞) 抑制 HIF-1 信号通路，具有低细胞毒性[1]。 7-Hydroxyneolamellarin A (0-100 μM; 12 h) 以剂量依赖性方式降低 Hela 细胞中 VEGF 的 mRNA 水平[1]。 7-hydroxyneolamellarin A (0-50 μM; 36 h) 抑制 Hela 细胞迁移、侵袭和增殖[1]。 Western Blot Analysis[1] Cell Line: Hela cells, MCF-7 cells and 4T1 cells Concentration: 0, 50, 100, and 150 μM Incubation Time: 12 hours Result: Decreased the HIF-1α protein levels in a dose-dependent manner. |
| In Vivo | 7-Hydroxyneolamellarin A (15 mg/kg; i.v.; 具有 4T1 细胞异种移植物的 BALB/c 小鼠) 抑制体内肿瘤生长[1]。 Animal Model: BALB/c mice with 4T1 cells xenografts[1] Dosage: 15 mg/kg Administration: Intravenous injection; every 2 days for 16 days Result: Inhibited tumor growth in vivo. |
| References |
| Molecular Formula | C24H19NO5 |
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| Molecular Weight | 401.41 |